Remote patient care and treatment through telemedicine provides healthcare organizations with the ability to increase patient-provider interaction at a lower overall cost of service at a rapid internet speed. In addition to improved patient care and convenience, telemedicine provides the societal benefit of extending quality healthcare to rural and other under served areas and may reduce the overall carbon footprint of healthcare delivery. This guide explores and summarized the unique physical infrastructure requirements and best practices for creating and maintaining a telemedicine center, whether in an existing healthcare setting or as a stand-alone facility.